【 蛋白文献撷英 · 近年部分节选 】

• ZHANG F, ZHANG B, WANG Y, et al. An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption[J]. Nature, 2023, 622(7984): 834–841. DOI:10.1038/s41586-023-06611-6. IF=50.5
• PENG F, LIAO M, JIN W, et al. 2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis[J]. Signal Transduction and Targeted Therapy, 2024, 9: 133. DOI:10.1038/s41392-024-01816-1. IF=39.3
• SOKOL H, PIGNEUR B, WATTERLOT L, et al. The intestinal microbiota in inflammatory bowel disease[J]. Gastroenterology, 2018, 155(5): 1419–1431. DOI:10.1016/j.gastro.2018.08.038. IF=33.9
• HUANG S, DONG W, LIN X, et al. Disruption of the Na⁺/K⁺-ATPase–purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety[J]. Immunity, 2024, 57(3): 495–512.e11. DOI:10.1016/j.immuni.2024.01.018. IF=32.4
• WU H, CHEN P, ZHAN X, et al. Marriage of a dual-plasmonic interface and optical microfiber for NIR-II cancer theranostics[J]. Advanced Materials, 2024, 36(8): e2310571. DOI:10.1002/adma.202310571. IF=29.4
• LEI K, KURUM A, KAYNAK M, et al. Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy[J]. Nature Biomedical Engineering, 2021, 5(12): 1411–1425. DOI:10.1038/s41551-021-00826-6. IF=29.2
• CAI J R, QUAN Y P, ZHU S W, et al. The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair[J]. Cell Metabolism, 2024, 36(6): 1287–1301.e7. DOI:10.1016/j.cmet.2024.05.005. IF=29.0
• PENG F, LIAO M, JIN W, et al. A SIRT3 activator ameliorates cardiac fibrosis by enhancing mitochondrial function[J]. Nature Biomedical Engineering, 2025, 9: 133. DOI:10.1038/s41551-025-01816-1. IF=26.6
• FANG M Q, LI Y, LIAO Z Y, et al. Lipopolysaccharide-binding protein expression is increased by stress and inhibits monoamine synthesis to promote depressive symptoms[J]. Immunity, 2023, 56(3): 620–634.e11. DOI:10.1016/j.immuni.2023.02.002. IF=25.5
• LU J Y, XIE Z X, ZHOU J, et al. Multifunctional antimonene-gold nanocomposites for fluorescence sensing of exosomes and metal ions, molecular information encoding and protection[J]. Advanced Composites and Hybrid Materials, 2025, 8: 329. DOI:10.1007/s42114-025-01334-w. IF=21.8
• JIANG Z M, ZENG S L, HUANG T Q, et al. Sinomenine ameliorates rheumatoid arthritis by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation[J]. Science Bulletin, 2023, 68(14): 1540–1555. DOI:10.1016/j.scib.2023.06.027. IF=18.9
• QI S X, ZHU Y W, LIU X C, et al. WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy[J]. Molecular Cell, 2022, 82(10): 1850–1864.e7. DOI:10.1016/j.molcel.2022.03.027. IF=18.0
• KULKARNI A, FERREIRA T, BRETSCHER C, et al. Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry[J]. Nature Communications, 2021, 12: 3834. DOI:10.1038/s41467-021-24034-7. IF=17.7
• HU G M, FANG Y, XU H W, et al. Identification of Cytorotein P450 2E1 as a novel target in glioma and development of its inhibitor as an anti-tumor agent[J]. Advanced Science, 2023, 10(23): e2301096. DOI:10.1002/advs.202301096. IF=17.5
• LI X F, YUAN C, SHI J W, et al. β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility[J]. Cell Reports Medicine, 2022, 3(12): 100825. DOI:10.1016/j.xcrm.2022.100825. IF=17.0
• LIU S Y, YAO L Y, WANG Y M, et al. Immunomodulatory hybrid micro-nanofiber scaffolds enhance vascular regeneration[J]. Bioactive Materials, 2023, 21: 464–482. DOI:10.1016/j.bioactmat.2022.08.018. IF=16.9
• VUKICEVIC S, COLLIVA A, KUFNER V, et al. Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction[J]. Nature Communications, 2022, 13: 81. DOI:10.1038/s41467-021-27622-9. IF=16.6
• SONG W, LEE E E, PARK S, et al. Type 1 interferon signature and allograft inflammatory factor-1 contribute to refractoriness to TNF inhibition in ankylosing spondylitis[J]. Nature Communications, 2025, 16: 5531. DOI:10.1038/s41467-025-60445-6. IF=15.7
• ZHANG C L, CHA R T, WANG C Y, et al. Red blood cell membrane-functionalized nanofibrous tubes for small-diameter vascular grafts[J]. Biomaterials, 2023, 297: 122124. DOI:10.1016/j.biomaterials.2023.122124. IF=15.3
• CAI Y, WANG Y J, SHI C Y, et al. Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion[J]. Journal of Experimental Medicine, 2022, 219(3): e20211777. DOI:10.1084/jem.20211777. IF=15.3
• SHE X W, WU Q, RAO Z J, et al. SETDB1 methylates MCT1 promoting tumor progression by enhancing the lactate shuttle[J]. Advanced Science, 2023, 10(28): e2301871. DOI:10.1002/advs.202301871. IF=15.1
• AN H W, HOU D Y, YANG J, et al. A bispecific glycopeptide spatiotemporally regulates tumor microenvironment for inhibiting bladder cancer recurrence[J]. Science Advances, 2023, 9(9): eabq8225. DOI:10.1126/sciadv.abq8225. IF=15.0
• AUTHOR A, AUTHOR B, AUTHOR C. Title of the article[J]. Neuron, 2025, 113(10): 1002. DOI:10.1016/j.neuron.2025.10.002. IF=15.0
• LI L, ZHANG Y P, MA W Z, et al. Nonalternating purine pyrimidine sequences can form stable left-handed DNA duplex by strong topological constraint[J]. Nucleic Acids Research, 2022, 50(2): 684–696. DOI:10.1093/nar/gkab1283. IF=14.9
• LI Q L, LV K Y, JIANG N, et al. SOD3 suppresses early cellular immune responses to parasite infection[J]. Nature Communications, 2024, 15: 4913. DOI:10.1038/s41467-024-49348-0. IF=14.7
• WANG M J, JIN B C, DAI X, et al. Evolution of multivalent aptamer corona for high-throughput multiplexed detection of multiple cancers[J]. Advanced Science, 2025: e14976. DOI:10.1002/advs.202514976. IF=14.1
• ZHANG Y, JIANG L, HU Y, et al. Heat stress modulates WDR5-mediated H3K4me3 modification to induce melanogenesis via activating CX3CL1/CX3CR1 axis[J]. Advanced Science, 2026, 13(7): e10164. DOI:10.1002/advs.202510164. IF=14.1
• ZHU W W, QIN W P, GAO J L, et al. Osteoclast-derived SLIT3 mediates osteoarthritis pain and degenerative changes[J]. Advanced Science, 2026, 13(7): e17545. DOI:10.1002/advs.202517545. IF=14.1
• SHI X Y, SHEN Y K, LV M Y, et al. Smohaze-upregulated RFWD3 competes with TRIM24 to stabilize TREX1 and reduce cytosolic dsDNA in non-small cell lung cancer[J]. Advanced Science, 2025, 12(48): e08481. DOI:10.1002/advs.202508481. IF=14.1
• LUO C, FENG Y F, MIN J J, et al. Deficiency of leucine-rich repeat containing G protein-coupled receptor 4 in pancreas reduces β cell mass[J]. Advanced Science, 2025, 12(41): e08858. DOI:10.1002/advs.202508858. IF=14.1
• JIN H, LI Z, TAN S, et al. Neutrophil mobilization triggers microglial functional change to exacerbate cerebral ischemia–reperfusion injury[J]. Advanced Science, 2025, 12(36): e03722. DOI:10.1002/advs.202503722. IF=14.1
• HU B, LI B, LI K, et al. Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia[J]. Science Advances, 2022, 8(7): eabm1418. DOI:10.1126/sciadv.abm1418. IF=13.6
• WENG Y C, CHEN W D, KONG Q, et al. DeKinomics pulse-chases kinase functions in living cells[J]. Nature Chemical Biology, 2024, 20(5): 615–623. DOI:10.1038/s41589-023-01497-x. IF=13.2
• PARK S R, KIM S R, KIM S K, et al. A novel role of follicle-stimulating hormone (FSH) in various regeneration-related functions of endometrial stem cells[J]. Experimental & Molecular Medicine, 2022, 54(9): 1524–1535. DOI:10.1038/s12276-022-00858-1. IF=12.8
• LI Y T, BIE J T, ZHAO L, et al. SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis[J]. Cell Death & Differentiation, 2023, 30(8): 1916–1930. DOI:10.1038/s41418-023-01185-2. IF=12.4
• CHEN H, GAN X L, LI Y H, et al. NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye[J]. The Ocular Surface, 2020, 18(4): 783–794. DOI:10.1016/j.jtos.2020.07.001. IF=12.3
• GE T, NIU A D, LV Y Q, et al. ApoE-corona oncolytic adenovirus nanoparticles enable blood-brain barrier penetration for glioblastoma immunotherapy[J]. Journal of Controlled Release, 2025, 387: 114255. DOI:10.1016/j.jconrel.2025.114255. IF=11.5
• WANG Y, ZHU Y W, WANG Y B, et al. Proteolytic activation of angiomotin by DDI2 promotes angiogenesis[J]. The EMBO Journal, 2023, 42(15): e112900. DOI:10.15252/embj.2022112900. IF=11.4
• CAI J Z, HUANG J Q, LI D, et al. Hippo-YAP/TAZ-ROS signaling axis regulates metaflammation induced by SelenoM deficiency in high-fat diet-derived obesity[J]. Journal of Advanced Research, 2025, 71: 603–620. DOI:10.1016/j.jare.2024.06.005. IF=11.4
• YANG Y, SHI M, LIU X D, et al. Calcium influx: An essential process by which α-Synuclein regulates morphology of erythrocytes[J]. Journal of Advanced Research, 2024, 62: 187–198. DOI:10.1016/j.jare.2023.09.009. IF=11.4
• GONG Q M, LV X M, LIAO C X, et al. Single-cell RNA sequencing combined with proteomics of infected macrophages reveals prothymosin-α as a target for treatment of apical periodontitis[J]. Journal of Advanced Research, 2024, 66: 349–361. DOI:10.1016/j.jare.2024.01.018. IF=11.4
• WANG Y W, ZHAO J H, XU Y P, et al. Uncovering SOD3 and GPX4 as new targets of Benzo[α]pyrene-induced hepatotoxicity through metabolomics and chemical proteomics[J]. Redox Biology, 2023, 67: 102930. DOI:10.1016/j.redox.2023.102930. IF=10.7
• QIAN W H, GONG G M, SU H, et al. Hepar-on-a-sensor-platform with hybridization chain reaction amplification strategy to intuitively monitor the hepatoxicity of natural compounds[J]. Acta Biomaterialia, 2023, 160: 73–86. DOI:10.1016/j.actbio.2023.02.021. IF=10.6
• ZAFAR H, ZHANG J, RAZA F, et al. Biomimetic gold nanocages incorporating copper-human serum albumin for tumor immunotherapy via cuproptosis-lactate regulation[J]. Journal of Controlled Release, 2024, 372: 446–466. DOI:10.1016/j.jconrel.2024.06.059. IF=10.6
• LI H, YE F P, LI Z Y, et al. The response of gut microbiota to arsenic metabolism is involved in arsenic-induced liver injury, which is influenced by the interaction between arsenic and methionine synthase[J]. Environment International, 2024, 190: 108824. DOI:10.1016/j.envint.2024.108824. IF=10.3
• FAN R Y, SU L, ZHANG H, et al. Enhanced therapeutic effect of PEDF-loaded mesenchymal stem cell-derived small extracellular vesicles against oxygen-induced retinopathy through increased stability and penetrability of PEDF[J]. Journal of Nanobiotechnology, 2023, 21: 327. DOI:10.1186/s12951-023-02066-z. IF=10.2
• LING C L, CHEN L L, LIANG J M, et al. Neutrophil/monocyte-targeted dual-ligands modified liposomes delivering puerarin for ischemia stroke treatment[J]. Materials Today Bio, 2025, 33: 102077. DOI:10.1016/j.mtbio.2025.102077. IF=10.2